Tuesday, April 30, 2013

Psychometry: Best Psychic Exercises |

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Source: http://netskillsforlife.org/psychometry-best-psychic-exercises/

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Monday, April 29, 2013

Kobo Aura HD Review: A Beautiful Reader Screen Trapped in an Ugly Body

Everyone loves a pretty screen. The Kobo Aura HD is aiming to lead that charge in the ereader space. Armed with a best-in-class screen and an unusually powerful processor under the hood, the Aura HD tries its best to be a real luxury reader. It doesn't quite make it.

What Is It?

A front-lit ebook reader with a big, high-resolution screen.

Who's It For?

Readers who really, really want a pretty screen and more power than usual under the hood.

Design

The Kobo Aura HD's body is smooth plastic, unlike the Kindle Paperwhite's black soft-touch coating. It has two buttons at the top, one to wake the device, the other to toggle the front-light. The Aura HD is stark and simple from the front, but its back is contorted into a strange, asymmetric design intended to invoke crumpled paper or something like it. This back is awkward to look at and to hold. It's got a very distinctive look, but it sacrifices any semblance of comfort. And since the Aura HD is using infrared touch tech instead of the capacitive found in the Kindle Paperwhite, it?s got more bulk than you?d expect in a brand new ereader.

Using It

The Aura HD has that 6.8-inch 1080?1440, 265 DPI screen, and it really is world class. With the backlight off, it feels like you could be looking at ink on paper, and to the extent you might scrutinize the edges of the letters in the words in your ebook, that's nice. But it?s not a massive step ahead of the fidelity of the Kindle Paperwhite or Kobo Glo, really. The extra screen space doesn?t really add enough real estate to make much of a difference?especially not at the cost of a larger body.

Physically, the Aura is just slightly too wide to be comfortable for one-handed use. Palming it requires a bit of straining, and if you opt to hold it by the corner, its weight will get the better of you. This is compounded by the odd angles on the side of the Aura HD, which make holding it by the very edge slipperier than it ought to be.

The Aura also has a 1 GHz processor, but you'd be hard-pressed to really notice; the infrared screen effectively throttles max speed, so it?s hard to differentiate. There's cloud-syncing built in if you read books across devices (in a Kobo app on a phone, for instance) and the reader's achievement system is cute, if superfluous.

Kobo's software has been problematic in the past, and it still has its annoying quirks. Brightness, font-size, and other options are all controlled by finicky draggable bars when they'd be better suited software buttons, since it?s still using IR touch tech.

The Best Part

The screen. It?s wonderful. Large and beautiful and bright. Oh, it?s very bright. While it might not be a humongous improvement over other high quality E Ink screens out there, it?s a wonderful thing to look at.

Tragic Flaw

Everything but the screen. Compared to its contemporaries, the Aura HD is large, heavy, and awkward. For every second you find yourself thinking "this screen is nice!" there will be five where you think "I wish I wasn't holding this!"

This Is Weird...

The back of the Aura is just bizarrely designed. If you set the Aura HD on its back on a flat surface and poke the corner, it wobbles slightly. It?s ugly and uncomfortable to hold and it makes you wonder if the back's shape was decided at random.

Test Notes

  • At its max, the Aura's backlight is stronger than the Paperwhite's, and more even around the edges. The downside is that it tends to bleed through the text at higher levels, and the contrast suffers.
  • Kobo rates the Aura HD's batter as lasting 2 months?backlight on or off?with 30 minutes of reading a day. Over about half a week of heavier use (45-60 minutes, backlight on, brightness at 50 percent) we took it down to about 70 percent.
  • The Kobo store has about 2.5 million books, newspapers, and magazines, coming out just slightly on top of Amazon?s 2 million Kindle store results. You?ll have no trouble finding best-sellers at either store, though Amazon?s prices are occasionally a few dollars cheaper than Kobo?s offerings. And Kobo has no lending system in place, unlike both Amazon and Barnes and Noble, so expect to pay for everything you want to read.

Should You Buy It?

No. The Kobo Aura HD has a really nice screen, sure, but everything around that screen just drags it down. From the ergonomically bizarre design to its weight and size, the actual meat of the Aura HD is just not up to snuff. And besides that, pushing an E Ink screen's resolution this high is sort of a questionable pursuit here. You don?t need that extra resolution to read, and it?s reached a point of diminishing returns. That screen?s not nice enough to cancel out other basic problems with the design.

Props to Kobo for being the best at something, but the compromises born of that tunnel vision aspiration are just too high. At $169 the Kobo Aura HD is too expensive for something that does the wrong things right and the right things wrong.

Kobo Aura HD

? Display: 6.8 inches, 265 dpi, 1440 x 1080 resolution

? Dimensions: 6.91 x 5.05 x 0.46 in (175.7 x 128.3 x 11.7 mm)

? Weight: 8.5 oz (240g)

? Storage: 4 GB, microSD expansion slot

? Connectivity: Wi-Fi only

? Color: "Espresso, Ivory, or Onyx"

? Supported File Types: EPUB, PDF, and MOBI, CBR, CBZ

? Price:$169

Source: http://gizmodo.com/kobo-aura-hd-review-a-beautiful-reader-screen-trapped-5995330

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Refresh Roundup: week of April 22nd, 2013

Refresh Roundup week of April 22nd, 2013

Your smartphone and / or tablet is just begging for an update. From time to time, these mobile devices are blessed with maintenance refreshes, bug fixes, custom ROMs and anything in between, and so many of them are floating around that it's easy for a sizable chunk to get lost in the mix. To make sure they don't escape without notice, we've gathered every possible update, hack, and other miscellaneous tomfoolery we could find during the last week and crammed them into one convenient roundup. If you find something available for your device, please give us a shout at tips at engadget dawt com and let us know. Enjoy!

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Source: http://www.engadget.com/2013/04/28/refresh-roundup/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Sony Xperia Tablet Z available for preorder, includes free cradle offer

Sony Xperia Tablet Z

Preorder a 32GB version in white by May 24 to qualify for a free cradle

Sony has officially started taking preorders for its newest 10.1-inch Jelly Bean tablet, the Xperia Tablet Z. This incredibly thin, IR-sporting device was announced in late January, and shown off during the Mobile World Congress. It comes with a 'Full HD Reality Display' (1920x1200p WUXGA), 1.5GHz Snapdragon S4 Pro processor with 2GB RAM, a 2MP camera up front, and an 8MP camera in the rear.

To help up-sell those considering the $499.99 16GB black model, Sony is throwing in a free cradle accessory to customers that preorder a $599.99 32GB model in white. The 32GB version comes in black as well, but for whatever reason the free accessory offer only applies to the white version. Preorders must be in by May 24 to be eligible for a free cradle.

Head over to the Sony Tablet preorder page to reserve yours. If you're still on the fence, check out our initial hands-on, as well as the subsequent hands-on of this gorgeous tablet.

Source: Sony

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/hJWFFFQO8_w/story01.htm

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WH: Anthony Foxx in line for transportation post

FILE - In this Sept. 4, 2012 file photo, Charlotte Mayor Anthony Foxx addresses the Democratic National Convention in Charlotte, N.C. President Barack Obama on Monday will nominate Foxx as his new transportation secretary, a White House official said Sunday, April 28, 2013. (AP Photo/J. Scott Applewhite, File)

FILE - In this Sept. 4, 2012 file photo, Charlotte Mayor Anthony Foxx addresses the Democratic National Convention in Charlotte, N.C. President Barack Obama on Monday will nominate Foxx as his new transportation secretary, a White House official said Sunday, April 28, 2013. (AP Photo/J. Scott Applewhite, File)

(AP) ? President Barack Obama on Monday will nominate Charlotte, N.C., Mayor Anthony Foxx as his new transportation secretary, a White House official said Sunday.

If confirmed by the Senate, Foxx would replace outgoing Secretary Ray LaHood.

Foxx is Obama's first black nominee among the new Cabinet members appointed for the second term. The president faced criticism early in his second term for a lack of diversity among his nominees.

The official insisted on anonymity to avoid public discussion of the pick before the official announcement.

The official noted that Foxx has led efforts to improve his city's transit infrastructure to expand economic opportunity for businesses and workers. During Foxx's term as mayor, Charlotte has broken ground on several important transportation projects, including the Charlotte Streetcar Project to bring modern electric tram service to the city as well as a third parallel runway at Charlotte/Douglas International Airport. The city has also moved to extend the LYNX light rail system to the University of North Carolina at Charlotte, the official said.

Foxx, an attorney who has worked in several positions with the federal government, was first elected mayor in 2009. He also served as a member of the Charlotte City Council.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-28-Obama-Foxx/id-462bf5307e4d47fea0aa92e359433c32

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When pizza and gaming collide | GamesRadar

By the early 90s, Raphael, Leonardo, Donatello, and Michelangelo were the foremost experts on footclan shredding, sewer living, and pizza eating. It was only a matter of time before one of the major pizza chains hitched their ovens to TMNT's rising star, and lo and behold it was Pizza Hut who called dibs.

1990's TMNT: The Arcade Game port for the NES not only featured Pizza Hut logo throughout its backgrounds, but the game's manual included Pizza Hut coupons to help kids recreate their own ?Pizza Time!? in real life. Sadly, those coupons have long since expired, but Pizza Hut lives on forever in every copy of the TMNT arcade port.

Source: http://www.gamesradar.com/when-pizza-and-gaming-collide/

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5 of the Best Shopping Apps for Android - Android Apps - Best ...

shopping.appsShopping online has become the way to go these days, and shopping from your Android phone or tablet is about as simple as it gets. Our list of the Best Shopping Apps gives you 5 Free Android Apps that can make your life much easier by letting you browse, buy, and save money while you?re on the go.

1. Amazon Mobileamazon.app

Amazon is as great place to buy electronics, and there are thousands of digital goods to browse through. They also sell everything under the sun from laundry detergent to fish tanks and furniture. You?ll also get access to Gold Box Deals, and can use the barcode scanner to compare prices while you?re on the go. The Amazon Mobile App lets you access it all, and it?s by far one of the best shopping apps around. Amazon Mobile and Amazon Mobile for Tablets are both free to download on Google Play.


2. eBayebay.app

Amazon may have a ton of new merchandise, but they can?t hold a candle to eBay when it comes to variety. eBay is the place where you can find almost anything, and the official eBay app lets you browse, bid, and shop ?til you drop. The app is constantly updated with new features, and it?s the only app you?ll ever need if you want to shop on eBay. You can download the official eBay app for free on Google Play.


3. RetailMeNot Couponsretailmenot

If you?re a coupon clipper that wants to leave a pocketful of paper behind then you?ll want to check out RatailMeNot Coupons. This handy little app lets you save while you?re on the go with offering up hundreds of thousands of coupons from all the best stores. You can redeem in-store coupons directly from your favorite Android device, save them or even share deals with friends. It will definitely save you some money, and it?s a sure-fire lock for any list of the best shopping apps. RetailMeNot Coupons is free to download on Google Play, and we highly advise you to check it out.



4. RedLaser Barcode & QR Scannerredlaser

This one was tough as there are several great Barcode scanners out there, but RedLaser is a favorite of ours and has been one of the most consistent one?s we?ve tried. RedLaser lets you scan products to find the best deals around, and it will even let you buy products straight from select retailers. You can create shopping lists, get product reviews, and even make your own personalized QR code. It will scan and read almost anything you throw at it, and it?s free to download on Google Play.


5. CLapp ? Craigslist for Androidclapp.android

If you still want to wheel and deal online, but like to keep things local then Craigslist is the thing for you. Browsing the site can be a pain, but CLapp from Trixiesoft makes things easy with it?s simple to use interface. The app won?t let you post, but you can search the site easily to find deals locally or abroad. If you?re looking for a great way to browse Craigslist for deals, CLapp is the way to go and it?s free to download.

Source: http://android-apps.com/articles/5-of-the-best-shopping-apps-for-android/

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Saturday, April 27, 2013

Video: Gun Lobby Protest in Washington

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Source: http://www.nbcnews.com/video/cnbc/51664164/

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Panic Disorder: Self-help - DRN Health World - Tips For Healthy ...

You can do several things yourself to reduce panic attacks. If you decide to try self-help options, you can discuss with your health-care professional. Usually, they are effective in reducing panic episodes. There are several management options in self-help category.
  • Bibliotherapy
  • Support groups
  • Physical activities

Bibliotherapy is a programme, which includes reading materials depending on the principles of cognitive behavioural therapy (CBT). It helps deepen and broaden the person?s understanding of the panic disorder. Patient can read about the condition him or herself. Bibliotherapy encourages active participation of the person in the management and stimulates a stronger feeling of own responsibility for recovery. Additionally, the affected individuals can read about people, which have had the panic disorder and have coped effectively or recovered from the condition. Sometimes, the health-care professional may offer additional assignments or information to be completed during the daily routines. It accelerates the recovery.

Your health-care professional may help you to access to specific support groups. Sometimes, these groups operate by individuals, who have experienced the condition themselves and recovered from it.

They may ask you to do regular exercise. Physical activities cannot cure the panic disorder. However, they can enhance your mood.

Throughout the self-help therapy, you should see the health-care professional regularly, normally every four to eight weeks.

Related Links:

What Is Panic Disorder?
Planning the Management of Panic Disorder
Panic Disorder: Psychological Management
Panic Disorder: Pharmacological Management
What Is Generalised Anxiety Disorder (GAD)?

Source: http://www.drnhealth.com/2013/04/panic-disorder-self-help.html

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Leave Her Alone! Stars Defend Kim Kardashian?s Pregnancy Style

Celebs including Gwyneth Paltrow, Jenna Dewan-Tatum and Molly Sims react to critics of Kim Kardashian's maternity style and changing pregnant body.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/1KPZGqgjQoE/

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French journalist expelled from north Mali

BAMAKO, Mali (AP) ? The Malian military says it has expelled a French journalist from northern Mali who had documented civilian deaths blamed on Malian soldiers.

Lt. Col. Nema Sagara said Thursday that Dorothee Thienot, who has worked for French newspapers, was ordered by soldiers to leave the northern town of Gao.

Sagara said that Thienot had been trying to "ruin the image of the Malian military" with her reporting.

Earlier this year, Thienot was the first to document a number of bodies of civilians who had been thrown into a well in the central Malian town of Sevare.

Human rights groups have since accused Malian soldiers of killing civilians they accused of having links to Islamic extremists.

Thienot says she returned to the capital of Bamako after soldiers showed up at her place and demanded she leave Gao.

Source: http://news.yahoo.com/french-journalist-expelled-north-mali-131118507.html

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Friday, April 26, 2013

Amazon working on video streaming set-top box - Computer ...

CBR Staff Writer Published 25 April 2013

The device would compete with Apple TV, Roku and Google TV

Amazon is reportedly working on a television (TV) set-top box that would stream video over the Internet under its Instant Video -branded service.

The new device, which is anticipated to be launched during late 2013, will connect to TVs as well as allows accessing Amazon's expanding video services, such as the Amazon Video on Demand store.

The online retailer has been expanding its streaming video library to take on Netflix, Hulu, Time Warner's Home Box Office and others.

Recently, Amazon released its 14 pilot episodes of shows on the internet, including six shows for kids and eight comedies for free viewing.

The move would allow users give feedback on shows, upon which the Amazon Studios production firm would decide on which projects to be made into full TV series for viewing on subscription-based online video service Prime Instant Video.

Currently, Amazon users have to stream their content through specially equipped TVs, set-top boxes or videogame systems such as Microsoft's Xbox 360.

Earlier this year. Amazon revealed a plan to launch a subscription based streaming music service similar to Spotify.

Source: http://media.cbronline.com/news/amazon-working-on-video-streaming-set-top-box-250413

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Fathers, firefighters: Lives lost in West, Texas

This undated photo provided by Aderhold Funeral Home, Inc., show Kenneth "Luckey" Harris Jr. Harris was killed in the West, Texas fertilizer plant explosion. (AP Photo/Aderhold Funeral Home, Inc.)

This undated photo provided by Aderhold Funeral Home, Inc., show Kenneth "Luckey" Harris Jr. Harris was killed in the West, Texas fertilizer plant explosion. (AP Photo/Aderhold Funeral Home, Inc.)

This undated photo provided by Aderhold Funeral Home, Inc., show Perry Wayne Calvin. Calvin was killed in the West, Texas fertilizer plant explosion. (AP Photo/Aderhold Funeral Home, Inc.)

This undated photo provided by Marshall and Marshall Funeral Directors, shows Cyrus Adam Reed. Reed was killed in the West, Texas fertilizer plant explosion. (AP Photo/Marshall and Marshall Funeral Directors)

This undated photo provided by Aderhold Funeral Home, Inc., show Joseph F. Pustejovsky Jr. Pustejovsky was killed in the West, Texas fertilizer plant explosion. (AP Photo/Aderhold Funeral Home, Inc.)

This undated photo provided by Aderhold Funeral Home, Inc., show Douglas James Snokhous. Snokhous was killed in the West, Texas fertilizer plant explosion. (AP Photo/Aderhold Funeral Home, Inc.)

(AP) ? On April 17, an explosion at a fertilizer plant in West, Texas, leveled part of the small town located some 20 miles north of Waco. Most of the victims were first responders from fire departments in West and other nearby towns that were on the scene trying to control the fire that preceded the blast.

With help from relatives, friends, obituaries of the deceased released by local funeral homes and information provided at a memorial service, The Associated Press compiled vignettes of the 14 victims who died in the blast. They were a grandmother, a town secretary, a fire truck builder, a town festival organizer, a Superman fan, fishing enthusiasts, hunters, fathers, men preparing to become emergency medical technicians, and devoted church and local organization members.

Here are their stories:

KEVIN WILLIAMS SANDERS: Teacher, Superman fan

Sanders, 33, was known for his love of all things related to Superman. He and he and his wife, Sarah, named their son Reeve, after actor Christopher Reeve, who played the superhero in the movies.

Sanders grew up in the Chicago suburb of Palos Hills, Ill., and graduated from the University of Illinois with a bachelor's degree in animal science in 2001. He taught veterinary technician training at McLennan Community College in Waco. About 20 of his current and former McLennan Community College students attended a memorial service for some of the victims wearing T-shirts displaying the Superman emblem.

Sanders was a volunteer firefighter with the Bruceville-Eddy Volunteer Fire Department near West and was taking EMS class in West when the plant caught fire.

He is survived by his wife and 3-month-old son.

MORRIS BRIDGES JR.: Father, motorcyclist

Bridges, 41, had been with West's volunteer fire department for three years. His wife says his last words as he left home to fight the fertilizer plant fire were telling his infant son that he loved him and he'd be "right back." Bridges grew up in Dallas but lived in West. He loved to ride motorcycles and go fishing and camping. He is survived by his wife, Carmen, and three children.

WILLIAM "BUCK" UPTMOR: Fence-builder, musician, rodeo devotee

Uptmor, 45, owned a fence-building business and was supposed to start a job at a nearby ranch soon. Among other projects, Uptmor's company built the local cemetery's fence, said Bill McKown, a retired school superintendent from Abbott, Texas, a town six miles from West.

"He was always busy," building fences, McKown said. "Because he was very reliable."

Uptmor was the drummer for the band Billy Uptmor and the Makers. He enjoyed hunting, fishing, watching his children's sporting events, coaching Little League and supporting his daughter in barrel racing. He trained and jockeyed race horses and loved to rodeo, whether it was riding bulls or saddle and bareback broncos, according to an obituary released by a funeral home in West.

"I told him: 'You probably got every bone in your body broken.' And he said, 'That's probably true,'" McKown said.

He is survived by his wife of 13 years, Arcy Uptmor, his parents, two sons, a daughter, a grandmother, a brother, a sister and several nieces and nephews.

JOEY PUSTEJOVSKY: A caring, devout man

Joey Pustejovsky, 29, one of the volunteer firefighters killed in the blast, was the secretary for the town of West, said Veronica Felderhoff, a volunteer at the church where Pustejovsky's mother, Carolyn, works as a secretary to the rectory.

"He was a very caring person, always ready to help, a very devout Catholic," Felderhoff said. The Pustejovskys attended Mass every Sunday.

A funeral home obituary said Pustejovsky had been town secretary since 2009 and had worked as a personal property appraiser for McLennan County Appraisal District. He was a member of St. Mary's Catholic Church of The Assumption, where he started the youth ministry and was the director for two years of the Catholic Brothers and Sisters United Youth Ministry, the obituary said.

He loved spending time with his children and family as well as being involved in the community and his church.

The youngest of three brothers, Pustejovsky is survived by his wife, four children, his parents, a brother, grandmother and other relatives.

PERRY CALVIN: Father, husband, firefighter

Perry Calvin, 37, died responding to the fire at the fertilizer plant. His father, Phil Calvin, said Perry, a husband and father of two boys ages 9 and 2, was looking forward to his wife having a new baby around Thanksgiving.

He was a volunteer firefighter at the Navarro Mills and Martens fire departments and was attending EMS classes in West. He also was a student at the Hill County Fire College.

He was a self-employed farmer and loved the outdoors. He enjoyed horseback riding, rodeos, fishing and spending time with his family, a funeral home obituary said.

He is survived by his wife, Rebecca Ann Calvin, two sons, his father, a brother, two sisters, grandmother, nieces, nephews and other relatives.

JIMMY MATUS: Fire truck-builder and operator

Matus, 52, was killed while responding to the fire that caused the explosion. He was the sales manager at Westex Welding & Fire Apparatus, a company that builds fire trucks. For the past 40 years, he worked at the company and for the last half of that time he managed all aspects of the business, a funeral home obituary said.

"Jimmy was an outstanding man, someone who would go out of his way to help you. That's the way we are taught," said Garratt Matus of his father's cousin, Jimmy Matus.

Matus graduated from West High School in 1979.

He was a member of St. Mary's Catholic Church of the Assumption, SPJST Lodge 54, Sokol West and the State Fireman's Association, and an honorary member of the Masonic Lodge in West. He also served on the West ISD school board and played Santa Claus for local organizations, the obituary said.

He is survived by his parents, his son and daughter, two stepdaughters, two sisters, grandchildren, nieces and other relatives.

KENNETH HARRIS: Dallas firefighter

Dallas Fire-Rescue Capt. Kenneth Harris, 52, was off duty when the fire that caused the West Fertilizer explosion happened, but he still rushed to the emergency to offer his help to other firefighters responding to the scene.

"Captain Harris' response is typical of all our first responders; night and day, no matter where they are, no matter if they are on or off duty they respond with the greatest acts of bravery," Dallas City Manager Mary K. Suhm said in a statement.

Dallas Fire Chief Louie Bright III said, "Our hearts are heavy and hurting with the loss of such a great firefighter, great husband and great family man."

Harris graduated from the Dallas Fire Academy in 1982 and served as a firefighter with the Dallas Fire Department for more than 31 years. He also owned Harris Home Inspections and Construction with his family, a funeral home obituary said.

He loved offshore fishing with his sons and spending time on his boat the "Boots Up." He was a member of High Point Church in Waco and the Dallas Firefighters Association-Local 58.

He is survived by his wife of 28 years, Holly Harris of West; three sons; parents; two sisters; nieces and a nephew.

DOUGLAS SNOKHOUS: Firefighter, father, hunter

Douglas J. "Doug" Snokhous, 50, had been a firefighter with the West Fire Department for more than 15 years. He and his brother, Robert, were among the first responders killed in the blast.

"We are comforted they were together at the end," the Snokhous family said in a statement.

Snokhous was a shop supervisor at the Central Texas Iron Works in Waco, where he had worked for the past 29 years, according to a funeral home obituary.

A native of Hillsboro, Snokhous graduated from West High School in 1980.

He loved Westfest and the West Rodeo. He liked to fish and hunt deer and quail. He especially cherished spending time with his new grandson.

He and his brother, Robert, were inseparable. They worked, hunted, golfed and fought fires together.

Doug Snokhous is survived by his wife of 12 years, Donna Snokhous; two daughters; three stepchildren; a brother; a sister; his grandson; three stepgrandchildren; and several great nieces and nephews.

ROBERT SNOKHOUS: Firefighter, father

Capt. Robert Snokhous, 48, died with his brother doing one of the things the two of them loved: responding to an emergency in their community.

Born in 1964 in Hillsboro, Robert Snokhous graduated from West High School in 1982 and received an associated degree from Texas State Technical College in Waco. He worked at Central Texas Iron Works in Waco, where he was project manager. He had worked there for almost 20 years, the Snokhous family said in a statement.

He was a member of St. Mary's Catholic Church of the Assumption and the Knights of Columbus West Council No. 2305. He loved hunting and the West Volunteer Fire Department outdoor cook-offs.

He is survived by his wife of 13 years, Alison Snokhous; a son; two daughters; a brother; a sister; two grandchildren; several nieces and nephews; and other relatives.

CODY DRAGOO: Firefighter, NASCAR fan, family man

Cody Frank Dragoo, 50, a member of the West Volunteer Fire Department, also worked at the fertilizer plant. He was one of the first responders killed in the explosion.

Dragoo was born in Billings, Mont., and graduated from Montana State University with a degree in agriculture, a funeral home obituary said.

He enjoyed hunting, fishing, cooking, watching NASCAR and being with his family and friends, the obituary said.

Dragoo was a member of St. Mary's Catholic Church of the Assumption in West and the Knights of Columbus Council No. 2305. He was president of the Cottonwood Water Supply Corp.

He is survived by his wife, Patty Dragoo, two sisters, brothers-in-law, sisters-in-law as well as several nieces and other relatives.

JUDITH ANN MONROE: Grandmother, puzzle solver

Judith Ann Monroe, a native of Sinton, Texas, moved to West in 2001 from South Texas where she had lived most of her life. Called "Judy" by those who knew her, she enjoyed spending time with her family, especially her grandchildren, a funeral home obituary said.

Monroe, 65, loved reading, solving word puzzles and playing board games.

She is survived by her son, two grandchildren, a sister and other relatives.

MARIANO SALDIVAR: Loving husband and father

Mariano Saldivar, 57, lived in an apartment complex that was destroyed by the blast.

The Rev. Ed Karasek, pastor of the St. Mary's Catholic Church of the Assumption, said Saldivar would attend Mass every Sunday with his wife and daughter. "He was a faithful and loving husband and father," Karasek said during a eulogy at Saldivar's funeral service.

"He trusted in God whenever any one (of his relatives) was away on a trip or was ill, at times of hardship or sadness, during the drought or at times of war, when he lost loved ones," Karasek said of Saldivar.

A native of Mexico, Saldivar moved to California where he worked in the warehousing industry until he retired in 2008, according to a funeral home obituary.

Saldivar is survived by his wife, three sons, a daughter, three brothers and nine sisters. He will be buried in Portland, Ore.

JERRY DANE CHAPMAN: Firefighter, video gamer, generous man

Jerry Dane Chapman, 26, was known for his passion for helping others, both those he knew and those he did not.

Chapman, one of the first responders killed in the blast at the fertilizer plant, died doing what he loved to do: serving and protecting others, a funeral home obituary said.

Chapman was an avid video gamer. After working at different types of jobs, he discovered his passion when he became a member of the Abbott Volunteer Firefighters and started training to become an emergency medical technician. He had passed his skills test and was near the end of his training.

He is survived by his parents, grandparents, a great-grandmother, a sister and other relatives.

CYRUS ADAM REED: First responder almost done with EMT training

Cyrus Adam Reed, 29, was in a classroom attending the last session of his training to be an emergency medical technician when he responded to his final emergency call, a funeral home obituary said.

Reed, one of the first responders killed in the explosion at the West Fertilizer plant, was a member of the Abbot and Bynum volunteer fire departments and West Ambulance.

The obituary described him as having an "infectious smile," ''a giant heart" and "a dedication to honor of which he would not compromise."

He is survived by his grandmother, parents, a sister and several other relatives.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-25-Plant%20Explosion-Victims/id-5c1c3d8b4c4d49ffb44b1e743bb479f3

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Thursday, April 25, 2013

Senator aims for bipartisan trade promotion bill

By Doug Palmer

WASHINGTON (Reuters) - An influential Democratic senator said on Wednesday he was working on a bipartisan bill to boost President Barack Obama's ability to negotiate trade deals, but Republicans have made clear that more White House involvement is needed to pass the measure.

"I would like to see a bipartisan TPA (trade promotion authority) bill introduced by June," Senate Finance Committee Chairman Max Baucus said at a hearing on the Trans-Pacific Partnership pact, a proposed free trade agreement among 12 countries on both sides of the Pacific.

Approving the measure would help the White House conclude the three-year-old Asia-Pacific trade talks, which were expanded on Saturday to include Japan, Baucus said.

The Montana Democrat, who has been a driving force in Congress behind trade legislation, announced on Tuesday that he plans to retire at the end of his term next year.

Passing trade promotion authority this year would be a major achievement, setting the stage for votes on both the Trans-Pacific Partnership pact and another proposed free trade agreement with the European Union.

Representative Dave Camp, the Republican chairman of the House of Representatives Ways and Means Committee, also wants to move quickly on a bill on trade promotion authority, said a spokeswoman for that panel.

Karan Bhatia, a former U.S. trade official now a senior counsel and vice president at GE, underscored the need to pass TPA to finish the Trans-Pacific deal, which is expected to cover about 40 percent of global economic output.

"If the goal is to close this agreement done this year, I think we need to get TPA and we need to get it relatively soon," Bhatia referring to the current target of finishing talks on the Trans-Pacific pact in 2013.

Trade promotion authority, also known as "fast-track" trade legislation, allows the White House to submit trade deals to Congress for straight up-or-down votes without any amendments.

The legislation, which expired in 2007, is considered essential to assure other countries that any deals they reach with the United States will not be picked apart by Congress.

Staff on both the Senate Finance Committee and the House of Representatives Ways and Means Committee have already begun work on TPA legislation, which could face strong resistance from many Democratic who believe trade deals lead to U.S. job losses.

Senator Robert Casey, a Pennsylvania Democrat, said he had a "high degree of skepticism" about the Trans-Pacific Partnership pact because of the potential for job losses in the U.S. auto sector and other industries.

Obama has not formally requested TPA from Congress, although acting U.S. Trade Representative Demetrios Marantis told the Senate Finance Committee last month the administration was prepared to work with lawmakers on a bill.

Senator John Thune, a South Dakota Republican, said he worried that White House foot-dragging on the legislation could lead to delays in concluding the Trans-Pacific talks.

"We know renewal of TPA is likely to be contentious and it's going to take time, obviously, for Congress to work through the process," Thune said, urging the White House to put a greater priority on passing the bill.

Senator Orrin Hatch, the senior Republican on the Finance Committee, echoed those concerns.

"I have yet to see any real commitment on the part of the White House to achieving (TPA's) quick consideration and approval in Congress," he said.

"A formal request from the administration for TPA would send a strong signal to our negotiating partners and the proponents of the Trans-Pacific Partnership that the president is serious about making sure the rhetoric surrounding the agreement meets the reality of the negotiating table," Hatch said.

(Reporting by Doug Palmer; Editing by Neil Stempleman and Christopher Wilson)

Source: http://news.yahoo.com/senator-aims-bipartisan-trade-promotion-bill-192714564--business.html

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Rare galaxy found furiously burning fuel for stars

Wednesday, April 24, 2013

Astronomers have found a galaxy turning gas into stars with almost 100 percent efficiency, a rare phase of galaxy evolution that is the most extreme yet observed. The findings come from the IRAM Plateau de Bure interferometer in the French Alps, NASA's Wide-field Infrared Survey Explorer and NASA's Hubble Space Telescope.

"Galaxies burn gas like a car engine burns fuel. Most galaxies have fairly inefficient engines, meaning they form stars from their stellar fuel tanks far below the maximum theoretical rate," said Jim Geach of McGill University, lead author of a new study appearing in the Astrophysical Journal Letters.

"This galaxy is like a highly tuned sports car, converting gas to stars at the most efficient rate thought to be possible," he said.

The galaxy, called SDSSJ1506+54, jumped out at the researchers when they looked at it using data from WISE's all-sky infrared survey. Infrared light is pouring out of the galaxy, equivalent to more than a thousand billion times the energy of our sun.

"Because WISE scanned the entire sky, it detected rare galaxies like this one that stand out from the rest," said Ned Wright of UCLA, the WISE principal investigator.

Hubble's visible-light observations revealed that the galaxy is extremely compact, with most of its light emanating from a region just a few hundred light-years across.

"This galaxy is forming stars at a rate hundreds of times faster than our Milky Way galaxy, but the sharp vision of Hubble revealed that the majority of the galaxy's starlight is being emitted by a region just a few percent of the diameter of the Milky Way. This is star formation at its most extreme," said Geach.

The team then used the IRAM Plateau de Bure Interferometer to measure the amount of gas in the galaxy. The ground-based telescope detected millimeter-wave light coming from carbon monoxide, an indicator of the presence of hydrogen gas, which is fuel for stars. Combining the rate of star formation derived with WISE, and the gas mass measured by IRAM, the scientists get a measure of the star formation efficiency.

The results reveal that the star-forming efficiency of the galaxy is close to the theoretical maximum, called the Eddington limit. In regions of galaxies where new stars are forming, parts of gas clouds are collapsing due to gravity. When the gas is dense enough to squeeze atoms together and ignite nuclear fusion, a star is born. At the same time, winds and radiation from stars that have just formed can prevent the formation of new stars by exerting pressure on the surrounding gas, curtailing the collapse.

The Eddington limit is the point at which the force of gravity pulling gas together is balanced by the outward pressure from the stars. Above the Eddington limit, the gas clouds would be blown apart, halting star formation.

"We see some gas outflowing from this galaxy at millions of miles per hour, and this gas may have been blown away by the powerful radiation from the newly formed stars," said Ryan Hickox, an astrophysicist at Dartmouth College, Hanover, N.H., and a co-author on the study.

Why is SDSSJ1506+54 so unusual? Astronomers say they're catching the galaxy in a short-lived phase of evolution, possibly triggered by the merging of two galaxies into one. The star-formation is so ferocious that in a few tens of millions of years, the blink of an eye in a galaxy's life, the gas will be used up, and the galaxy will mature into a massive elliptical galaxy.

The scientists also used data from the Sloan Digital Sky Survey, the W.M. Keck Observatory on Mauna Kea, Hawaii and the MMT Observatory on Mount Hopkins, Arizona.

###

McGill University: http://www.mcgill.ca

Thanks to McGill University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127889/Rare_galaxy_found_furiously_burning_fuel_for_stars

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95% Gimme The Loot

All Critics (40) | Top Critics (22) | Fresh (38) | Rotten (2)

A thousand-watt jolt of mischief, a spunky, funky, ebullient indie that packs its 81 minutes with cinematic exhilaration.

It may be a slight movie, but it has its sunny charms.

A movie about teenage taggers in the Bronx should be fast and raw, scruffy and loose, and Adam Leon's Gimme the Loot is just that.

As it lopes along, the movie offers a warm but very sharp portrait of New York's have-nots and their uneasy relationship with the haves.

"Gimme the Loot" shouldn't be as appealing and exuberant as it is, it really shouldn't.

Tashiana Washington and Ty Hickson are terrific in the main roles. So is Zo? Lescaze as Ginnie, a spoiled white kid who teaches the taggers a thing or two about drift and being dissolute.

Simultaneously real and hopeful, "Loot" has almost no plot, but when the setting is so fresh and the characters feel so raw and alive, who needs one?

Ghetto laughs with a sophisticated point of view.

...a magical, summery treat.

Promotes robbery and can't be serious in expecting us to care whether Malcolm and Sofia become more than friends.

The winner of the Indie Spirit 'One to Watch' award could never work again and will always have a memorable New York City film to his credit.

An impressive debut feature, Gimme the Loot is also an unusual take on characters who want to leave their stamp on "the city that never sleeps."

Much more grownup than it looks, Gimme the Loot is that rare teen-centric film whose brisk pace is unburdened by sentimentality.

Writer-director Adam Leon has crafted a classic New York story, a film imbued with the fast rhythms and muggy sensations of city life during the summer.

No quotes approved yet for Gimme The Loot. Logged in users can submit quotes.

Source: http://www.rottentomatoes.com/m/gimme_the_loot_2012/

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Israel: OK to check emails of foreigners at border

(AP) ? Israel's attorney general on Wednesday upheld a practice to allow security personnel to read people's email accounts when they arrive at the airport, arguing it prevents militants from entering the country.

The ruling followed an outcry last year when some people trying to enter Israel were ordered to open their emails after hours of interrogation at Israel's Ben-Gurion airport. In one instance, three Palestinian-American women were forbidden from entering after email checks were conducted.

Critics say it primarily targets Muslims and Arabs and appears to be aimed at keeping out visitors who have histories of pro-Palestinian activism, citing a history of such people being turned away from Israel's border crossings.

Security personnel may ask visitors to open their email accounts for inspection if they are perceived as being suspicious, wrote Nadim Aboud of Israel's attorney general office. In a response to the Association for Civil Rights in Israel, he said potential entrants may refuse to allow their emails to be checked, but that would be a factor in deciding whether a person would be allowed to enter the country.

Aboud said the checks were justified because there was an increasing risk of foreigners being involved in militant activity. He said security services could not properly investigate the backgrounds of some potential entrants without the additional check.

A Justice Ministry official said the search was conducted only in "extraordinary cases." He spoke anonymously in line with ministry policy.

The attorney general's office wrote the letter in response to a request for clarification by ACRI after incidents were reported last year, said attorney Lila Margalit of the organization. She said Aboud's response effectively legalized the checks, which could now be challenged only in court.

"It was a concern because of the level of invasion inherent in (checking) a personal email account," Margalit said. "It constitutes a violation of privacy."

She said inside Israel, police could search a person's computer data only with court approval, even if there was a criminal investigation underway.

Israeli officials tend to conduct exhaustive checks on foreigners entering the country, or passing through border crossings they control, if they are deemed suspicious.

It particularly affects people who hope to travel to Palestinian areas of the West Bank. The Palestinians a measure of self-government in the West Bank, a territory east of the Jewish state; but Israel controls entry into those areas.

Such visitors frequently complain that they risk not being allowed into the country if they announce they will visit areas under Palestinian Authority control; but risk being accused of lying if they omit that information to security investigators.

There are no statistics on how many people are refused entry into Israel or through border crossings that Israel controls.

One aspect of the issue is that most people entering Israel obtain visas at the airport or other border crossings. Unlike many countries, Israel does not require people to obtain visas from their embassies in advance of their trips, eliminating possible screening before visitors arrive in Israel.

In contrast, Israelis themselves are required to obtain visas far in advance before visiting many countries. Even the U.S. requires an exhaustive interview process at its embassy in Tel Aviv, and it does not grant visas to all who apply. Iranian-born Israelis, for example, are often refused visas.

The practice of email checks appears to be a step beyond what some Western countries allow, while others permit similar measures.

Germany does not allow such searches. The U.S. Department of Homeland Security has seized computers and other electronic devices from people arriving in the United States to search them.

In a narrow ruling last month, the Ninth U.S. Circuit Court of Appeals ruled that while Customs and Border Protection officers can do "a quick look" at a laptop computer or other equipment, reasonable suspicion is required for a more in-depth forensic exam of electronics. It was not immediately clear if that included email.

___

AP writers Alicia A. Caldwell in Washington and Robert Reid in Berlin contributed.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-24-ML-Israel-Email-Search/id-b1b4bcf4c51d46ed912a424792988f16

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On Hold: Genes That Pause Pregnancy Discovered

Unlike human women, female mice and some other mammals can delay the onset of their pregnancies, and researchers have now identified the molecular mechanism behind this remarkable ability.

The phenomenon, known as embryonic diapause, is a temporary state of suspended animation that occurs when environmental conditions are not favorable to the survival of the mother and the newborn. A new study, published online today (April 23) in the journal Open Biology,?reveals the genes that are responsible for pausing and resuming a pregnancy.

After an egg is fertilized, it forms a cluster of cells known as a blastocyst, which implants in the wall of the mother's uterus. But during diapause, the blastocyst is prevented from implanting and preserved in an inactive state until pregnancy resumes. Yet exactly how this process occurred was a mystery. [Gallery: Evolution's Most Extreme Mammals]

Sudhansu Dey, of Cincinnati Children's Research Foundation, and colleagues were studying the process of embryo implantation in mice when they noticed that a gene called MSX1 was very active just before implantation. They began to suspect that it might play a role in diapause, Dey told LiveScience.

To investigate further, Dey's team used hormones to induce pregnancy delays in mice, mink and Tammar wallabies. During this delayed state, the researchers measured how active the MSX1 gene and other related genes were in generating protein-making instructions. Then, they imaged tissue from the animals to see where the gene was active. Finally, they tested whether these genes were being made into proteins.

They found that the MSX genes were more active when pregnancies were delayed, and found this was true for all three animals. The genes were primarily active in epithelial cells, the type of cells that line body cavities such as the interior of the uterus, results showed. The experiments also confirmed that these genes were indeed making proteins.

Dey said the results are very exciting ? they show that MSX genes, which are part of an ancient family of genes, have been preserved over much of evolutionary time, and play an important role in delaying pregnancy under harsh conditions.

Dey wants to know whether the same genes may enable delayed pregnancies in other animals, such as the polar bear or giant panda.

Ultimately, a deeper understanding of diapause could have implications for humans, Dey said. "If we keep MSX1 maintained at higher levels in human [women], maybe we can extend the receptive phase" for fertilization, he said, though he added that such an extension may be many years away. ?

Follow Tanya Lewis on Twitter?and Google+.?Follow us @livescience, Facebook?& Google+. Original article on?LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/hold-genes-pause-pregnancy-discovered-230723879.html

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Psychopaths are not neurally equipped to have concern for others

Apr. 24, 2013 ? Prisoners who are psychopaths lack the basic neurophysiological "hardwiring" that enables them to care for others, according to a new study by neuroscientists at the University of Chicago and the University of New Mexico.

"A marked lack of empathy is a hallmark characteristic of individuals with psychopathy," said the lead author of the study, Jean Decety, the Irving B. Harris Professor in Psychology and Psychiatry at UChicago. Psychopathy affects approximately 1 percent of the United States general population and 20 percent to 30 percent of the male and female U.S. prison population. Relative to non-psychopathic criminals, psychopaths are responsible for a disproportionate amount of repetitive crime and violence in society.

"This is the first time that neural processes associated with empathic processing have been directly examined in individuals with psychopathy, especially in response to the perception of other people in pain or distress," he added.

The results of the study, which could help clinical psychologists design better treatment programs for psychopaths, are published in the article, "Brain Responses to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals with Psychopathy," which appears online April 24 in the journal JAMA Psychiatry.

Joining Decety in the study were Laurie Skelly, a graduate student at UChicago; and Kent Kiehl, professor of psychology at the University of New Mexico.

For the study, the research team tested 80 prisoners between ages 18 and 50 at a correctional facility. The men volunteered for the test and were tested for levels of psychopathy using standard measures.

They were then studied with functional MRI technology, to determine their responses to a series of scenarios depicting people being intentionally hurt. They were also tested on their responses to seeing short videos of facial expressions showing pain.

The participants in the high psychopathy group exhibited significantly less activation in the ventromedial prefrontal cortex, lateral orbitofrontal cortex, amygdala and periaqueductal gray parts of the brain, but more activity in the striatum and the insula when compared to control participants, the study found.

The high response in the insula in psychopaths was an unexpected finding, as this region is critically involved in emotion and somatic resonance. Conversely, the diminished response in the ventromedial prefrontal cortex and amygdala is consistent with the affective neuroscience literature on psychopathy. This latter region is important for monitoring ongoing behavior, estimating consequences and incorporating emotional learning into moral decision-making, and plays a fundamental role in empathic concern and valuing the well-being of others.

"The neural response to distress of others such as pain is thought to reflect an aversive response in the observer that may act as a trigger to inhibit aggression or prompt motivation to help," the authors write in the paper.

"Hence, examining the neural response of individuals with psychopathy as they view others being harmed or expressing pain is an effective probe into the neural processes underlying affective and empathy deficits in psychopathy," the authors wrote.

The study with prisoners was supported with a $1.6 million grant from the National Institute of Mental Health.

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The above story is reprinted from materials provided by University of Chicago, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jean Decety, Laurie R. Skelly, Kent A. Kiehl. Brain Response to Empathy-Eliciting Scenarios Involving Pain in Incarcerated Individuals With Psychopathy. JAMA Psychiatry, 2013 DOI: 10.1001/jamapsychiatry.2013.27

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/uRcT0SkoiG0/130424161108.htm

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Rocket Internet-Backed Fashion Portal Zalora Launches iOS App, No Word Of Android Yet

Zalora logoZalora, Rocket Internet's pan-Asian fashion retail site, has launched an iOS app, as it seeks to capture the growing base of consumers in Asia who are using smartphones as their primary, and sometimes only, way of getting online.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/c-Fmj7Iewq0/

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Pitt team finds melatonin delays ALS symptom onset and death in mice

Pitt team finds melatonin delays ALS symptom onset and death in mice [ Back to EurekAlert! ] Public release date: 25-Apr-2013
[ | E-mail | Share Share ]

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine. In a report published online ahead of print in the journal Neurobiology of Disease, the team revealed that receptors for melatonin are found in the nerve cells, a finding that could launch novel therapeutic approaches.

Annually about 5,000 people are diagnosed with ALS, which is characterized by progressive muscle weakness and eventual death due to the failure of respiratory muscles, said senior investigator Robert Friedlander, M.D., UPMC Endowed Professor of neurosurgery and neurobiology and chair, Department of Neurological Surgery, Pitt School of Medicine. But the causes of the condition are not well understood, thwarting development of a cure or even effective treatments.

Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, the research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death.

"Our experiments show for the first time that a lack of melatonin and melatonin receptor 1, or MT1, is associated with the progression of ALS," Dr. Friedlander said. "We saw similar results in a Huntington's disease model in an earlier project, suggesting similar biochemical pathways are disrupted in these challenging neurologic diseases."

Hoping to stop neuron death in ALS just as they did in Huntington's, the research team treated mice bred to have an ALS-like disease with injections of melatonin or with a placebo. Compared to untreated animals, the melatonin group developed symptoms later, survived longer, and had less degeneration of motor neurons in the spinal cord.

"Much more work has to be done to unravel these mechanisms before human trials of melatonin or a drug akin to it can be conducted to determine its usefulness as an ALS treatment," Dr. Friedlander said. "I suspect that a combination of agents that act on these pathways will be needed to make headway with this devastating disease."

###

Co-authors of the paper include other scientists from the University of Pittsburgh School of Medicine; Harvard Medical School; Ohio State University; Weifang Medical University; Bedford VA Medical System, Boston; St. Joseph's Hospital and Medical Center, Phoenix; University of Texas Medical School at Houston; and VA Pittsburgh Health Care System.

The project was funded by grants NS051756, NS039324, and NS055072 of the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health; the U.S. Department of Defense; and the Muscular Dystrophy Association.

About the University of Pittsburgh School of Medicine

As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1998. In rankings recently released by the National Science Foundation, Pitt ranked fifth among all American universities in total federal science and engineering research and development support.

Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see http://www.medschool.pitt.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Pitt team finds melatonin delays ALS symptom onset and death in mice [ Back to EurekAlert! ] Public release date: 25-Apr-2013
[ | E-mail | Share Share ]

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences

Melatonin injections delayed symptom onset and reduced mortality in a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to a new study by researchers at the University of Pittsburgh School of Medicine. In a report published online ahead of print in the journal Neurobiology of Disease, the team revealed that receptors for melatonin are found in the nerve cells, a finding that could launch novel therapeutic approaches.

Annually about 5,000 people are diagnosed with ALS, which is characterized by progressive muscle weakness and eventual death due to the failure of respiratory muscles, said senior investigator Robert Friedlander, M.D., UPMC Endowed Professor of neurosurgery and neurobiology and chair, Department of Neurological Surgery, Pitt School of Medicine. But the causes of the condition are not well understood, thwarting development of a cure or even effective treatments.

Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, the research team determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death.

"Our experiments show for the first time that a lack of melatonin and melatonin receptor 1, or MT1, is associated with the progression of ALS," Dr. Friedlander said. "We saw similar results in a Huntington's disease model in an earlier project, suggesting similar biochemical pathways are disrupted in these challenging neurologic diseases."

Hoping to stop neuron death in ALS just as they did in Huntington's, the research team treated mice bred to have an ALS-like disease with injections of melatonin or with a placebo. Compared to untreated animals, the melatonin group developed symptoms later, survived longer, and had less degeneration of motor neurons in the spinal cord.

"Much more work has to be done to unravel these mechanisms before human trials of melatonin or a drug akin to it can be conducted to determine its usefulness as an ALS treatment," Dr. Friedlander said. "I suspect that a combination of agents that act on these pathways will be needed to make headway with this devastating disease."

###

Co-authors of the paper include other scientists from the University of Pittsburgh School of Medicine; Harvard Medical School; Ohio State University; Weifang Medical University; Bedford VA Medical System, Boston; St. Joseph's Hospital and Medical Center, Phoenix; University of Texas Medical School at Houston; and VA Pittsburgh Health Care System.

The project was funded by grants NS051756, NS039324, and NS055072 of the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health; the U.S. Department of Defense; and the Muscular Dystrophy Association.

About the University of Pittsburgh School of Medicine

As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1998. In rankings recently released by the National Science Foundation, Pitt ranked fifth among all American universities in total federal science and engineering research and development support.

Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see http://www.medschool.pitt.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/uops-ptf042413.php

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