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Wednesday, April 24, 2013

Samsung Galaxy S 4 coming to AT&T stores April 27th, pre-orders arrive April 25th

Pre-orders of the Samsung Galaxy S 4 have already begun at AT&T, but the operator has been oddly silent about the actual date customers can expect to purchase one in stores and online. Now that T-Mobile and Sprint have both announced specific launch dates (April 24th and 27th, respectively), the largest GSM carrier in the country has followed up by declaring its intent to sell the flagship Samsung device on the 27th of this month. This is four days earlier than the anticipated pre-order shipment date, which means the HTC One has merely a full week to bask in the spotlight by itself. What's more, if you simply couldn't wait and jumped on those pre-orders, you'll get yours a full 48 hours early (read: April 25th). As expected, the GS 4 will be offered for $200 (16GB) and $250 (32GB) in both black and white.

[Thanks to everyone who sent this in]

Filed under: Cellphones, Wireless, Mobile, Samsung, AT&T

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Source: AT&T (Twitter), AT&T

Source: http://www.engadget.com/2013/04/22/samsung-galaxy-s-4-coming-to-atandt-stores-april-27th/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Tuesday, April 23, 2013

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Source: http://soliloquize-hyde.blogspot.com/2013/04/proven-article-marketing-tips-writing.html

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Obama Promotes Science Careers at White House Fair

[unable to retrieve full-text content]At the White House Science Fair on Monday, President Obama announced a plan to encourage the study of science, technology, engineering and math.

Source: http://www.nytimes.com/2013/04/23/us/politics/obama-promotes-science-careers-at-white-house-fair.html?partner=rss&emc=rss

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Egypt justice minister submits resignation

CAIRO (AP) ? A government spokesman says Egypt's justice minister has submitted his resignation after the president's supporters engaged in violent street clashes with opponents over calls to "cleanse the judiciary."

Supporters of President Mohammed Morsi want him to purge the judiciary of former regime supporters. Many opponents of the call view it as an attempt by Islamists to control the judiciary.

Cabinet spokesman Alaa el-Hadidy says Justice Minister Ahmed Mekky submitted his resignation on Sunday. The presidency did not immediately say if the resignation was accepted.

In a copy of his resignation obtained by The Associated Press, Mekky says Friday's protests led to the decision. He also mentions a new law being discussed in parliament that could dismiss 3,500 of Egypt's approximately 13,000 judges and prosecution officials by lowering the retirement age.

Source: http://news.yahoo.com/egypt-justice-minister-submits-resignation-143111926.html

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Sunday, April 21, 2013

Study upends model of how dividing cells monitor distribution of chromosomes

Apr. 21, 2013 ? Ludwig researchers Arshad Desai and Christopher Campbell, a post-doctoral fellow in his laboratory, were conducting an experiment to parse the molecular details of cell division about three years ago, when they engineered a mutant yeast cell as a control that, in theory, had no chance of surviving. Apparently unaware of this, the mutant thrived.

Intrigued, Campbell and Desai began exploring how it had defied its predicted fate. As detailed in the current issue of Nature, what they discovered has overturned the prevailing model of how dividing cells ensure that each of their daughter cells emerge with equal numbers of chromosomes, which together package the genome. "Getting the right number of chromosomes into each cell is absolutely essential to sustaining life," explains Desai, PhD, a Ludwig member at the University of California, San Diego, "but it is also something that goes terribly wrong in cancer. The kinds of mistakes that occur when this process isn't functioning properly are seen in about 90% of cancers, and very frequently in advanced and drug-resistant tumors."

Campbell and Desai's study focused in particular on four interacting proteins known as the chromosomal passenger complex (CPC) that monitor the appropriate parceling out of chromosomes. When cells initiate division, each chromosome is made of two connected, identical sister chromatids -- roughly resembling a pair of baguettes joined in the middle. As the process of cell division advances, long protein ropes known as microtubules that extend from opposite ends of the cell hook up to the chromosomes to yank each of the sister chromatids in opposite directions. The microtubules attach to the chromatids via an intricate disc-like structure called the kinetochore. When the protein ropes attach correctly to the sister chromatids, pulling at each from opposing sides, they generate tension on the chromosome. One of the four proteins of the CPC, Aurora B kinase, is an enzyme that monitors that tension. Aurora B is expressed at high levels in many cancers and has long been a target for the development of cancer therapies.

Aurora B is essentially a molecular detector. "If the chromosomes are not under tension," says Desai, "Aurora B forces the rope to release the kinetochore and try attaching over and over again, until they achieve that correct, tense attachment."

The question is how? Aurora B is ordinarily found between the two kinetochores in a region of the chromosome that links the sister chromatids, known as the centromere. The prevailing model held that the microtubule ropes would pull themselves, and the kinetochores, away from Aurora B's reach, so that it cannot force the microtubule ropes to detach from their captive chromosomes. In other words, the location of Aurora B between the two kinetochore discs was thought to be central to its role as a monitor of the requisite tension. "This matter was thought settled," says Desai.

Yet, as Campbell and Desai show through their experiments, yeast cells engineered to carry a mutant CPC that can't be targeted to the centromere survive quite vigorously. They demonstrate that in such cells Aurora B instead congregates on the microtubule ropes. There, it somehow still ensures that the required tension is achieved on chromosomes before they are parceled out to daughter cells.

How precisely it does this remains unclear. Campbell and Desai provide evidence that the clustering of Aurora B on microtubules might be sufficient to activate its function. At the same time, they hypothesize, appropriate tension on the chromosome may induce structural changes in Aurora B's targets that make them resistant to its enzymatic activity. Campbell and Desai are now conducting experiments to test these ideas.

This work was supported by the Ludwig Institute for Cancer Research, the National Institutes of Health (GM074215) and the Damon Runyon Cancer Research Foundation Fellowship (DRG 2007-09).

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The above story is reprinted from materials provided by Ludwig Institute for Cancer Research, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Christopher S. Campbell and Arshad Desai. Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Nature, 2013 DOI: 10.1038/nature12057

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/sAYVqaJuguw/130421151620.htm

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Saturday, April 20, 2013

casca news: CASCA: Job postings/Offres d'emploi

(English follows)

Les offres d'emploi suivantes viennent d'?tre ajout?es ? notre banque.

-Programs Officer/personne charg?e de programmes
D?veloppement et Paix/Development and Peace

-Anthropology Sessional Faculty
University of the Fraser Valley

-SSHRC - Canada Research Chair (CRC) Tier 2 in Indigenous Studies. Queen?s
University

-Anthropology - Assistant Professor (Anthropology of Religion)
York University

-Anthropology - Assistant Professor (Power, Politics and Development) York
University

-Sociology - Assistant Professor (Sociology of Health Care, Health and
Illness)
University of Saskatchewan

-Sociology - Instructor
Kwantlen Polytechnic University

-D?veloppement international et mondialisation - Deux Professeur-e-s
rempla?ant-e-s
Universit? d'Ottawa

-International Development and Global Studies - Two Replacement
Faculty Positions
University of Ottawa

-FACULTY OF ARTS TERM POSITION IN ANTHROPOLOGY
University of Regina

-Chair - Department of Sociology
McMaster University

-Community Health Sciences - Director, Manitoba First Nations Centre for
Aboriginal Health Research (MFN CAHR).
University of Manitoba

-Sociologie et Anthropologie - Professeurs rempla?ants (2)
Universit? d'Ottawa

-Sociology and Anthropology - Faculty Replacement Positions (2)
University of Ottawa

-Sociology - Assistant Professor (Two-Year Term Appointment)
The University of Winnipeg

-Peace Studies - Lecturer or Assistant Professor
McMaster University

-Indigenous Studies - Assistant Professor (Indigenous Health and Wellness)
University of Sudbury

-Anthropology - Instructor (Biological/Forensic Anthropology)
Kwantlen Polytechnic University

-Anthropology - Instructor (Cultural)
Kwantlen Polytechnic University

-Sociology/Criminology - Assistant Professor
Western University

Consultez-les ou voyez toute la liste en visitant notre site Web:

www.cas-sca.ca

Merci

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